Synthetic Calcite as a Scaffold for Osteoinductive Bone Substitutes
نویسندگان
چکیده
منابع مشابه
Osteoinductive ceramics as a synthetic alternative to autologous bone grafting.
Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating ...
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One of the most difficult challenges in orthopaedics is the treatment of large bone voids or defects. While autografts have traditionally been considered a standard treatment, this procedure has been associated with complications such as increased incidence of pain, nerve injury, arterial damage, harvest site fracture, hematoma, infection, and compromised patient function. Synthetic bone graft ...
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Spherical carbonate apatite (CO3Ap) microspheres approximately 1 mm in diameter were fabricated by granulation of calcium hydroxide around a core followed by carbonation and phosphatization through dissolution-precipitation reaction. CO3Ap microspheres with high uniformity could not be achieved without using a core. Solid CO3Ap microspheres were obtained using a calcite core whereas hollow CO3A...
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We describe a detailed embedding procedure for large bone specimens in methyl methacrylate and a new staining method by which thin sections (appr 100 um) of undecalcified bones with synthetic implants can be coloured. Different staining effects were obtained which greatly facilitated the evaluation of sections with bone, new forming bone and especially remnants of synthetic implants. The identi...
متن کاملDoped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes
Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the i...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2015
ISSN: 0090-6964,1573-9686
DOI: 10.1007/s10439-015-1520-3